Article
Update on long- and short-acting contraceptive methods
- Aust Prescr 2025;48:72-81
- 10 June 2025
- DOI: 10.18773/austprescr.2025.023
Long-acting reversible contraceptive methods, including the contraceptive implant and intrauterine devices, are highly effective and cost-effective options for women who have no specific contraindications. Long-acting reversible contraceptives are more effective at reducing unintended pregnancy than short-acting contraceptives.
Short-acting contraceptive methods consist of combined hormonal contraception (e.g. the combined oral contraceptive pill, vaginal ring), progestogen-only pills, and the progestogen-containing contraceptive injection.
Choice of contraception is based on factors such as medical eligibility (i.e. precautions, contraindications), patient preference and reproductive life stage.
Counselling patients on the benefits and risks of all contraceptive methods is important for informed decision-making. Regular contraceptive review can allow for patient education and monitoring of adverse effects.
It is estimated that around two-thirds of Australian women of childbearing age currently use a form of contraception.1,2 The combined oral contraceptive pill is the most commonly used method, followed by condoms.1,2
Long-acting reversible contraceptives (LARCs) include the contraceptive implant and intrauterine devices (IUDs) and are the most effective methods of contraception. The short-acting hormonal forms of contraception (e.g. combined oral contraceptive pill, progestogen-only pill, contraceptive injection, vaginal ring) are more user-dependent methods and their failure rates with typical (real-world) use are higher than LARCs.
The uptake of LARCs in Australia has slowly increased over the past decade. In 2018, it was estimated around 10.8% of women aged 15 to 44 years were using a LARC, with 4.5% using the contraceptive implant and 6.3% using an IUD.3 However, the proportion of women using LARCs in Australia is lower than in other countries of comparable development status;4 for example, in Sweden, a 2017 report found 30.9% of women were using a LARC.5
The reliance on less effective methods of contraception is reflected in the unintended pregnancy rate across Australia, estimated to be around 40%, and higher among women in rural areas.6 Around 30% of unintended pregnancies end in abortion,7 and continuing unintended pregnancies are associated with poorer maternal and child outcomes.8 Increased LARC uptake results in a lower rate of unintended pregnancies and abortions, reducing the associated risks.9 The high effectiveness of LARCs in preventing unintended pregnancy makes them the most cost-effective forms of reversible contraception.10,11
Providing education around the range of contraceptive options, as well as removing barriers to access, is key to improving reproductive autonomy. There is good evidence that when barriers such as access and cost are removed, and the contraceptive and non-contraceptive effects of LARCs are explained, women are more likely to choose LARCs.9,10
This article provides an update on long- and short-acting contraceptive methods in Australia. The article also discusses the factors influencing choice of contraception, management of adverse effects, contraceptive considerations for different population groups, and means to increase contraceptive accessibility. Clinicians should be aware of barrier, permanent and other nonpharmacological forms of contraception, as well as emergency contraception, which are not discussed in this article.
This article focuses on contraceptive advice relevant for people with a uterus. While the word ‘women’ is occasionally used, the authors recognise that this information may be relevant to people with a range of gender identities.
In Australia, the following LARCs are available (Table 1):
Table 1 Long-acting reversible contraceptive methods available in Australia11-15
Contraceptive implant | Hormonal intrauterine devices | Copper intrauterine devices | ||
Brand example |
Implanon NXT |
Mirena |
Kyleena |
TT380 TT380 short Load 375 CU375 CU380 |
Hormone dose |
68 mg etonogestrel |
52 mg levonorgestrel |
19.5 mg levonorgestrel |
– |
Mechanism of action |
Thickens cervical mucus Inhibits ovulation Possibly thins endometrium |
Thickens cervical mucus Causes endometrial atrophy Affects sperm and oocyte motility Occasionally prevents ovulation |
Is toxic to sperm Has an endometrial effect |
|
Duration |
3 years |
8 years for contraception (except when inserted for contraception in women aged 45 years and older, in which case it can remain in situ until age 55) 5 years for endometrial protection with estrogen-containing menopausal hormone therapy |
5 years |
5 to 10 years (depending on device) |
Efficacy |
99.9% |
99.9% |
99.7% |
99.2% |
Effect on bleeding |
Variable bleeding patterns |
Reduction in bleeding Users may experience amenorrhoea or infrequent light bleeding |
Users may experience irregular bleeding |
Can increase menstrual bleeding and pain |
Other benefits |
Periods may be less painful |
Management of dysmenorrhoea and heavy menstrual bleeding Endometrial protection for users of estrogen-containing menopausal hormone therapy |
Slightly smaller device frame compared with Mirena [NB1]; may offer easier insertion for young and nulliparous women16 |
Can be used as emergency contraception if inserted within 5 days of unprotected intercourse |
PBS subsidy |
Yes |
Yes |
Yes |
No |
PBS = Pharmaceutical Benefits Scheme (Australia) NB1: Size of Kyleena: 28 × 30 mm frame; 3.8 mm inserter tube diameter; has a silver ring at neck. Size of Mirena: 32 × 32 mm frame; 4.4 mm inserter tube diameter; no silver ring at neck. |
In 2024, the approved duration of use for the 52 mg levonorgestrel IUD (Mirena) was extended from 5 to 8 years for the purpose of contraception in Australia.17 This change was based on data from a large US-based study that found the contraceptive efficacy of the Mirena IUD at 8 years was comparable with its efficacy at 5 years.18 The Mirena is approved for managing heavy menstrual bleeding for 5 years; however, if heavy menstrual bleeding has not returned, continuation up to 8 years may be considered.19 Extended use, beyond 5 years, of the 19.5 mg levonorgestrel IUD (Kyleena) is not recommended.
Short-acting contraceptive methods in Australia include (Table 2):
Table 2 Short-acting contraceptive methods available in Australia
Combined hormonal contraception | Progestogen-only methods | |||
Combined oral contraceptive pill | Vaginal ring | Progestogen-only pill20 | Contraceptive injection (depot medroxyprogesterone)13,21 | |
Brand example |
See Table 3 |
NuvaRing |
Noriday
|
Depo-Provera |
Hormone dose |
See Table 3 |
11.7 mg etonogestrel and 2.7 mg ethinylestradiol (120 micrograms etonogestrel and 15 micrograms ethinylestradiol daily) |
Noriday: 350 micrograms norethisterone Microlut: 30 micrograms levonorgestrel Slinda: 4 mg drospirenone |
150 mg medroxyprogesterone acetate |
Mechanism of action |
Inhibits ovulation Changes cervical mucus |
Thickens cervical mucus Inhibits ovulation (drospirenone only) |
Inhibits ovulation Changes cervical mucus to limit sperm penetration Causes endometrial changes unfavourable for implantation |
|
Dosing schedule |
Daily |
Placed in vagina for 3 weeks. Ring then removed, and a new ring inserted with an optional 7 day hormone break |
Daily |
Administered every 12 weeks If adminstered within 14 weeks of last injection, no additional contraception needed |
99.5% with perfect use 93% with typical use |
99.5% with perfect use 93% with typical use |
99.5% with perfect use 91% with typical use |
99.8% with perfect use 96% with typical use |
|
Effect on bleeding |
Typically reduced menstrual bleeding |
Variable |
Some patients may experience initial irregular bleeding; majority of users become amenorrhoeic over time |
|
Non-contraceptive benefits |
Reduced menstrual bleeding and pain May improve acne and hirsutism Reduced endometriosis recurrence after surgical management Reduced risk of some cancers |
Limited evidence; however, some suggestion that drospirenone may reduce dysmennorhoea, acne and hirsutism20 |
Amenorrhoea or reduced bleeding; may benefit those with heavy menstrual bleeding or endometriosis Discrete |
|
PBS subsidy |
See Table 3 |
No |
Yes (all) |
Yes |
PBS = Pharmaceutical Benefits Scheme (Australia) |
There are many combined oral contraceptive pills available in Australia (Table 3). The efficacies of all the preparations are considered equal. A newer combined oral contraceptive pill became available in Australia in 2022 (Nextstellis). It contains drospirenone, as the progestogen component, and estetrol, a newly created hormone compound that aims to match a form of naturally occurring estrogen. This combination offers the benefit of a low rate of unscheduled bleeding.23 Further, estetrol appears to have a minimal impact on haemostasis compared with other available estrogen preparations.23
Table 3 Combined oral contraceptive pills available in Australia24
Brand name | Estrogen | Progestogen | PBS listing |
Femme-Tab ED 20/100 Loette Microgynon 20 ED Micronelle 20 ED |
20 micrograms ethinylestradiol |
100 micrograms levonorgestrel |
Only Femme-Tab ED 20/100 listed on PBS |
Eleanor 150/30 ED Evelyn 150/30 ED Femme-Tab ED 30/150 Lenest 30 ED Leveth 150/30 ED Levlen ED Microgynon 30 ED Micronelle 30 ED Monofeme Seasonique |
30 micrograms ethinylestradiol |
150 micrograms levonorgestrel |
All are listed on the PBS |
Microgynon 50 ED |
50 micrograms ethinylestradiol |
125 micrograms levonorgestrel |
Yes |
Logynon ED Trifeme 28 Triquilar ED |
6 × 30 micrograms ethinylestradiol |
6 × 50 micrograms levonorgestrel |
All are listed on the PBS |
5 × 40 micrograms ethinylestradiol |
5 × 75 micrograms levonorgestrel |
||
10 × 30 micrograms ethinylestradiol |
10 × 125 micrograms levonorgestrel |
||
Norimin 28 Day |
35 micrograms ethinylestradiol |
500 micrograms norethisterone |
Yes |
Norimin-1 28 Day |
35 micrograms ethinylestradiol |
1000 micrograms norethisterone |
Yes |
Madeline Marvelon 28 |
30 micrograms ethinylestradiol |
150 micrograms desogestrel |
No |
Minulet |
30 micrograms ethinylestradiol |
75 micrograms gestodene |
No |
Brenda-35 ED Diane-35 ED Estelle-35 ED Jene-35 ED Juliet-35 ED |
35 micrograms ethinylestradiol |
2 mg cyproterone acetate |
No |
Bella Brooke Rosie Yana Yaz |
20 micrograms ethinylestradiol |
3 mg drospirenone |
Yaz only |
Brooklynn Isabelle Petibelle Rosalee Yasmin Yelena |
30 micrograms ethinylestradiol |
3 mg drospirenone |
Yasmin only |
Valette |
30 micrograms ethinylestradiol |
2 mg dienogest |
No |
Qlaira |
2 × 3 mg estradiol valerate |
– |
No |
5 × 2 mg estradiol valerate |
5 × 2 mg dienogest |
||
17 × 2 mg estradiol valerate |
17 × 3 mg dienogest |
||
2 × 1 mg estradiol valerate |
– |
||
Zoely |
1.5 mg estradiol |
2.5 mg nomegestrol acetate |
No |
Nextstellis |
14.2 mg estetrol |
3 mg drospirenone |
No |
PBS = Pharmaceutical Benefits Scheme (Australia) |
The vaginal ring is another form of combined hormonal contraception, having a similar mechanism, contraindications and precautions to the combined oral contraceptive pill (Table 2). The vaginal ring is not affected by gastrointestinal absorption and may benefit women with malabsorptive disorders who wish to use an estrogen-containing regimen.
There are 2 types of progestogen-only pills available in Australia (Table 2). ‘Traditional’ progestogen-only pills contain norethisterone (Noriday) or levonorgestrel (Microlut). Doses of these are considered ‘missed’ if they are taken more than 3 hours late.13
The second type of progestogen-only pill contains drospirenone (Slinda) which has been available in Australia since 2021. It differs from traditional progestogen-only pills in that it additionally prevents ovulation and has a 24-hour ‘missed pill’ window.13 The pill packs contain 24 active pills and 4 inactive pills, offering the potential for more predictable, scheduled bleeding patterns compared with traditional progestogen-only pills.25
A contraceptive injection that is available in Australia is depot medroxyprogesterone acetate (DMPA), a long-acting progestogen that is administered via intramuscular injection in either the gluteal site (preferred) or the deltoid muscle (Table 2). DMPA is associated with a small loss in bone density in users; however, this is thought to recover upon cessation.26 For women with additional risk factors for osteoporosis or younger women who have not reached their peak bone density, an alternative form of contraception may be more suitable. Prior to commencing DMPA, patients should be advised there may be a delay in return to fertility of up to 12 months,13,27 and those desiring pregnancy sooner, or women in the later stages of their fertility window, should consider an alternative contraceptive. Overseas, a contraceptive injection that may be patient-administered subcutaneously is available.
Many factors influence the choice of contraception, such as:28
General principles to consider when choosing contraception are in Box 1. The UK Medical Eligibility Criteria (UKMEC) provides comprehensive guidance on which contraceptive methods can be safely used, and when caution or contraindication is relevant to specific medical conditions, reproductive history, and clinical characteristics such as cardiovascular risk.29 The online UKMEC calculator is a helpful tool for clinicians when selecting a contraceptive method.
All patients should be offered education on the range of contraceptive options and select the most suitable contraception for them, in line with their medical eligibility (UK Medical Eligibility Criteria) and contraceptive needs.
All patients may be offered a long-acting reversible contraceptive as a first-line contraceptive option given their high efficacy, unless there are specific contraindications.
Contraceptive consultations are an opportunity to identify and manage other sexual health concerns such as screening for sexually transmitted infections, urogenital and gynaecological conditions, or sexual dysfunction.
Where appropriate, consider screening for domestic violence and reproductive coercion.
Arranging follow-up after starting contraception (e.g. after 3 months) can allow for monitoring of adverse effects, education on the chosen method, and adjustment of the method if needed.
Adverse effects can impact on a person’s wellbeing and the likelihood of continuing their chosen contraceptive method. LARC users are 3 times more likely to continue their contraceptive method compared with non-LARC users.30 In a large study, LARC continuation rates at 3 years were almost 70% compared with 31% for non-LARCs, with non-LARC users commonly discontinuing their contraception due to adverse effects. LARC users have been found to discontinue use due to irregular bleeding patterns and perceived feelings of decreased wellbeing.30
Counselling on adverse effects prior to starting a contraceptive and on review is an important part of providing contraceptive care. Evidence suggests that more intensive counselling may be associated with a decreased rate of discontinuation of short-acting contraceptives due to adverse effects.31 Common adverse effects and possible management strategies for LARCs and combined oral contraceptive pills can be found in Table 4.
Table 4 Managing common adverse effects of long-acting reversible contraceptive methods and combined oral contraceptive pills [NB1]11,14,32,33
Adverse effect | Management strategies |
Long-acting reversible contraceptive method (intrauterine devices and contraceptive implant) | |
Problematic bleeding |
Ensure adequate counselling on expected bleeding patterns before use. Clinical assessment and investigation (e.g. pregnancy test, cervical screening, testing for sexually transmitted infections, pelvic ultrasound) may be warranted to exclude underlying pathology. If no alternative cause of bleeding detected, provide education and reassurance. If bleeding frequent or prolonged, consider:
Other management strategies such as adding norethisterone or a progestogen-only pill have been suggested; however, evidence is currently limited. |
Hormonal adverse effects (e.g. headaches, mood changes, weight gain, breast tenderness, loss of libido) |
Review and manage any potential contributing lifestyle causes or factors. If symptoms are persistent and/or bothersome, consider alternative contraception. |
Combined oral contraceptive pills | |
Nausea |
Exclude pregnancy. Reduce estrogen dose. Take pills at night. Change to progestogen-only method. |
Breast tenderness |
Reduce estrogen and/or progestogen dose. Change progestogen – consider using a pill containing drospirenone (mild diuretic effect). |
Headache |
Reduce estrogen dose and/or change progestogen. If headache occurs in hormone-free week, consider one of the following:
|
Dysmenorrhoea |
Extend pill regimen to reduce the frequency of bleeding. |
Decreased libido |
No evidence supports a benefit of one type of oral contraceptive pill over another. |
Breakthrough bleeding |
If taking an ethinylestradiol 20‑microgram pill, increase estrogen dose to a maximum of 35 micrograms. Change progestogen if already taking an ethinylestradiol 30 to 35‑microgram pill. Consider alternative forms of contraception. |
Mood changes |
Seek medical review and assessment if new or worsening mood symptoms. Address other causes. Consider extended use or switching to a drospirenone regimen, particularly if symptoms premenstrual. |
Weight gain |
A causal association between combined hormonal contraception and weight gain has not been found. Identify and manage potential alternative causes. |
NB1: Adapted from reference 33 |
The most important drug interactions affecting hormonal contraception involve drugs that induce hepatic cytochrome P450 enzymes. Some examples include:
These drugs increase clearance of hormonal contraceptives and can reduce the effectiveness of all combined hormonal contraceptive methods, all progestogen-only pills, and the contraceptive implant.
Caution is advised with the use of hormonal contraceptives and antibiotics if the antibiotics are enzyme inducers (e.g. rifampicin, rifabutin) or the antibiotic (or the illness being treated) causes vomiting or diarrhoea.
The copper and hormonal IUDs are unaffected by liver enzyme–inducing drugs and are the preferred method where drug interactions are an issue.
Combined hormonal contraceptives are associated with an increased risk of venous thromboembolism (VTE) (3 to 15/10,000 woman-years in users versus 1 to 5/10,000 in non-users).35 This risk is still lower than the risk in pregnancy and appears to decline over time. The risk of VTE is significantly higher with pills containing 50 micrograms ethinylestradiol plus levonorgestrel compared with pills containing 20 micrograms ethinylestradiol.
Naturally based estrogens like estradiol valerate and estetrol have fewer VTE events reported.36,37
People with Factor V Leiden and other inheritable thrombophilias should not use combined hormonal contraceptives. For the combined oral contraceptive pill, the risk varies with the type of progestogen and is lowest in preparations containing progestogens such as levonorgestrel, and highest in pills such as desogestrel.
Progestogen in lower doses, as contained in the implant, pills and IUDs, do not increase the risk of VTE.38
The Royal Australian and New Zealand College of Obstetricians and Gynaecologists and the UK Faculty of Sexual and Reproductive Healthcare have comprehensive guidelines for contraceptive use in specific population groups. When used in conjunction with UKMEC, these guidelines can assist in selecting appropriate contraception. Key contraceptive considerations for selected population groups are summarised below.
Contraception should be initiated as soon as possible postpartum, as pregnancy can occur as early as 21 days after birth. Provision of postpartum contraception can optimise interpregnancy interval, as an interpregnancy interval of less than 12 months is associated with an increased risk of preterm birth, low birth weight and small-for-gestational-age babies.39 Antenatal contraceptive counselling can facilitate timely provision of the woman’s chosen method.
Not all contraceptive methods can be started early postpartum. Estrogen-containing contraception such as the combined oral contraceptive pill cannot be used immediately postpartum due to an increased risk of VTE. The timing of commencement depends on a range of factors including breastfeeding status. Practitioners should refer to the UKMEC, which provides detailed and specific guidance.29
The contraceptive implant, progestogen-only pill and contraceptive injection can be started at any time after birth. The hormonal IUDs may be inserted up to 48 hours after uncomplicated caesarean section or vaginal birth, otherwise at least 28 days after delivery (because of risk of perforation between 48 hours and 28 days after delivery). The risk of IUD expulsion is higher if inserted immediately after delivery; however, immediate insertion is associated with high continuation rates and a reduced risk of unintended pregnancy.
Progestogen-only methods of contraception can all be safely used in breastfeeding.
Contraception can be provided at the time of, or immediately after, an abortion unless medical contraindications exist.39
Copper and hormonal IUDs can be inserted at the time of surgical abortion at any gestation.43-45 They can be inserted after a medical abortion once expulsion of the products of conception has been confirmed, and post-abortion infection has been excluded.
Progestogen-only contraceptives can be initiated at any time following medical or surgical abortion. The contraceptive implant may be inserted at the time of prescribing or taking mifepristone. Administration of the contraceptive injection at the time of mifepristone administration has a slightly higher risk of continuing pregnancy and patients should be adequately counselled on the signs and symptoms of a failed abortion.
Combined hormonal contraception can be started at any time following an abortion.
Patients should be counselled that additional contraceptive precautions are required if contraception is initiated more than 5 days after an abortion.
Providers of contraception should assess the individual’s ability to provide consent using frameworks such as the Fraser guidelines or Gillick competence,46,47 consider the possibility of exploitation and coercion, and be aware of local mandatory reporting requirements. Young people should be informed of confidentiality and the limitations of this.
The high efficacy, reliability and ‘set and forget’ nature of LARCs may be attractive to young people. However, the need to see a healthcare professional and have a procedure to insert LARCs may be a barrier to their use.
The non-contraceptive benefits of the combined oral contraceptive pill, including improvement in symptoms of primary dysmenorrhoea and acne, may benefit young people affected by these conditions.
Given the potential for delay in return to fertility and potential decrease in bone mineral density associated with the contraceptive injection, alternative methods are preferred for those aged 18 years and under.
Effective contraception until menopause is required to prevent unintended pregnancy. Medical eligibility (UKMEC) should be carefully examined for each patient, as many women over 40 have elevated background risks of cardiovascular disease, VTE, and other comorbidities.
The contraceptive implant and progestogen-only pill can be safely used in women over 40, with no associated increased risk of VTE, stroke, myocardial infarction, or bone mineral density effect.
The 52 mg levonorgestrel IUD (Mirena) can be used for contraception until menopause or age 55 if inserted at age 45 or over, provided it is not being used for endometrial protection with menopausal hormone therapy (Table 1). The copper IUD can be used until menopause when inserted in women aged over 40 years.
Women over 40 using the contraceptive injection should be reviewed regularly to assess the risks and benefits in relation to bone mineral density. Women over 50 should use an alternative method.
The combined oral contraceptive pill may be used in women over 40 if they are medically eligible; however, women over 50 should use an alternative method. If the combined oral contraceptive pill is the chosen method in a woman over 40, consider prescribing pills containing a lower dose of estrogen (30 micrograms ethinylestradiol or less) and with levonorgestrel or norethisterone progestogen components, given their potentially lower risk of VTE, cardiovascular disease and stroke.
The potential non-contraceptive benefits of some contraceptives may be relevant to women in this age group. For example, the hormonal IUD may be used to manage heavy periods common in perimenopause, or the combined oral contraceptive pill may be used in medically eligible women to relieve the symptoms of menopause and prevent loss of bone mineral density.
While evidence suggests that body mass index (BMI) does not affect contraceptive efficacy (excluding that of emergency contraception), BMI may affect medical eligibility for certain contraceptive methods.
Estrogen-containing contraceptives are not recommended for women with a BMI of 35 kg/m2 or greater. In women with a BMI of 30 kg/m2 or greater, the use of the contraceptive injection has been associated with increased weight gain. A longer length needle may be required to administer intramuscular injections in women with obesity.
Women using weight loss medications that may cause diarrhoea or vomiting may experience reduced effectiveness of oral contraceptives. Women who have undergone weight loss surgery are recommended to use non-oral contraceptive methods given the potential issues with absorption.
Estrogen-containing contraceptives are contraindicated in individuals who experience migraine with aura. In those with a history (of at least 5 years) of migraine with aura or who develop a migraine without aura while using these methods, the use of the combined oral contraceptive pill or the vaginal ring is not recommended. Non-hormonal contraception such as the copper IUD, or any of the progestogen-only methods can be used by people experiencing migraine.29
A variety of strategies has been implemented and proposed to improve access to contraception in Australia, including:
LARCs are the most effective methods of contraception. Contraception prescribing should be guided by the individual’s medical eligibility and other factors such as reproductive life stage, drug interactions, reversibility and lifestyle. Education on the range of contraceptive options including a discussion around the risks and benefits of each method can empower individuals to choose their preferred contraceptive. Encouraging follow-up can offer the opportunity for managing adverse effects and providing ongoing sexual and reproductive health care. It is good practice to regularly reassess each woman’s contraceptive needs and medical eligibility as this will change over time.
This article was finalised on 13 May 2025.
Conflicts of interest: Emma Mason received funding from ASHM Health for conference attendance in 2024.
Kirsten Black is an investigator within the Centre of Research Excellence in Sexual and Reproductive Health for Women in Primary Care which is funded by the National Health and Medical Research Council. Kirsten has received research funding from the Women’s Plans Foundation, Department of Health and Aged Care, and the Medical Research Future Fund. Kirsten is the Chair of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists’ Special Interest Group in Sexual and Reproductive Health.
This article is peer reviewed.
Australian Prescriber welcomes Feedback.
Lecturer in Sexual and Reproductive Health, The University of Sydney
Professor of Sexual and Reproductive Health, The University of Sydney